Neuro-electronic interfaces play a fundamental role for studying brain functions and cellular mechanisms of information processing both in vitro and in vivo. Here we present a new concept in which electronic devices are integrated with models of neuronal networks of human origin together with nanotools to characterize the (patho)physiology of such in vitro complex systems. Large-scale CMOS micro-transducer arrays, coupled to 2D and 3D networks are presented together with new techniques for non-invasively modulate the cell activity. Specifically, piezo-electric nano particles and gold nano rods are used to excite-inhibit the neural activity that is recorded by the micro-transducer arrays. Concept, technology, and preliminary results are presented toward the implementation of a bio-hybrid brainon-a-chip.

Neuro-electronic devices and nanotools to interact with neuronal networks

M. Pisano;A. Spanu;
2020-01-01

Abstract

Neuro-electronic interfaces play a fundamental role for studying brain functions and cellular mechanisms of information processing both in vitro and in vivo. Here we present a new concept in which electronic devices are integrated with models of neuronal networks of human origin together with nanotools to characterize the (patho)physiology of such in vitro complex systems. Large-scale CMOS micro-transducer arrays, coupled to 2D and 3D networks are presented together with new techniques for non-invasively modulate the cell activity. Specifically, piezo-electric nano particles and gold nano rods are used to excite-inhibit the neural activity that is recorded by the micro-transducer arrays. Concept, technology, and preliminary results are presented toward the implementation of a bio-hybrid brainon-a-chip.
2020
978-1-7281-8888-1
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/20.500.12076/14224
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