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Integrative Bioinformatics Analysis: Unraveling Variant Signatures and Single-Nucleotide Polymorphism Markers Associated with 5-FU-Based Chemotherapy Resistance in Colorectal Cancer Patients

Sub-National Scale Initiatives for Climate Change Mitigation: Refining the Approach to Increase the Effectiveness of the Covenant of Mayors

Climate change mitigation strategies include sub-national initiatives proposed and operated by municipalities. An example of such initiatives is the Covenant of Mayors, the signatories of which are requested to compile territorial greenhouse gas emission inventories to identify entry points for mitigating policies and to be able to monitor their effectiveness over time. However, the current accounting approach presents some limitations, providing an incomplete picture of the territorial emiss...

The environmental footprints of the feeds used by the {EU} chicken meat industry

Chicken meat production in the European Union (EU) causes environmental pressures within and beyond the EU, mostly due to feed consumption. The expected dietary shift from red to poultry meat will drive changes in the demand for chicken feeds and the associated environmental impacts, calling for a renewed attention on this supply chain. By performing a break-down analysis based on material flow accounting, this paper assesses the annual environmental burden caused within and outside of the EU...

Exploring the potential of circular solutions to replace inorganic fertilizers in the European Union

The use of inorganic fertilizer in agriculture is linked to the consumption of finite mineral resources. The demand of inorganic fertilizer is unsustainable since the current practices mostly follow a linear economy pathway incurring in a significant loss of nutrients. Accordingly, circular solutions to close the nutrient loop should be implemented to increase the sustainability of agriculture. However, the implementation of circular solutions is neither straightforward nor always beneficial....

LCA based circularity indices of systems at different scales: a holistic approach

Many are the definitions of Circular Economy as well as the policies and strategies for its implementation. However, gaps still exist in quantifying the effects of circularity. The existing approaches are usually sector- or product-specific, limited to microscale systems, and/or fail to simultaneously assess the environmental impacts of the studied system. This paper introduces a generally applicable method in which a set of LCA-based indices of circularity are able to detect the effects of c...

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